Targeted delivery has a bottleneck.
We are a nonprofit startup building an open atlas of the human surfaceome — abundance, specificity, internalization, and routing — to scale targeted delivery beyond the liver.
Where things stand.
We've explored <0.4% of the available surfaceome.
01 — Mission
What if delivery were engineered?
The Deliverome Project is building a public atlas of receptors across tissues, cell types, and disease states — showing not just where they are expressed, but which are specific, internalize, and route cargo in useful ways. We share data, methods, and reagents openly, and collaborate across academia and industry to expand the set of validated targets for precision delivery far beyond today's narrow starting point.
02 — Platform
Three signals, one data resource.
Abundance & specificity, internalization, and trafficking — the key parameters that determine successful delivery — are still largely unmeasured and fragmented across disconnected datasets, labs, and proprietary systems. The Deliverome Project will measure all three and release them together as a unified, openly available dataset over the course of the project.
- i. Specificity & abundance
Tissue and disease-state quantitative precision.
Which receptors are present in the right places — and absent from the wrong ones? And how much of each receptor is actually on the cell surface? Receptors linked to specific tissues, cell types, or diseases need to be at the right levels for therapies to work. Quantitative mass spectrometry can build the protein-level atlas of the surfaceome needed to engineer precision medicines.
- ii. Internalization
Functional readouts of receptor-mediated uptake.
Once a therapeutic reaches the cell surface, can the target receptor actually bring it into the cell? Pooled functional genomics screens and enrichment-based mass spectrometry can rank surface receptors by how effectively they internalize cargo.
- iii. Trafficking
Functional genomics of routing and payload release.
Where does cargo go after it enters a cell — the endosome, lysosome, cytosol, nucleus, or back to the surface? Pooled functional genomics screens can map the routing decisions that determine whether a therapeutic reaches the right cellular destination for its intended effect.
03 — Stay close
Get release notes when new Deliverome data goes live.
Dataset drops, methods notes, and public release announcements,
roughly quarterly.